At 21 they diagnosed me with AD/HD & gave me smart pills. My grades shot up & my future brightened & some said I was better. But I am numb inside of this drug. People I love become distant strangers sometimes, so proud of me for victories I didn’t earn. How do I tell them I am not what I do or have done. I’ll never be happy on this drug, but I’ll never be successful without it. If only I could Love Adderall.
Yes, Generics must have the same active ingredients (80-120% of the amount is acceptable by the FDA).
Generics effect can be different because of the binders and fillers that effect its release in the body which is I think is the key to its effectiveness. If its released too fast you will experience symptoms of over stimulation (jittery, nervous, anxious, confused,…etc). It would also go out of your symptoms so fast that you experience big crash.
Imagine having a glass of wine every hour over 12 hours or so. You would feel alot better than drinking the whole bottle in 15 minutes.
Once the patent for the active ingredient expires, generic companies can copy the formula but binders and fillers which were developed by the brand manufacturer specifically for the active ingredient to be the smoothest release with the most benefit and least side effects are considered trade secrets that generics can’t touch. usually brand manufacturers spend billions of dollars on research and clinical trials to workout every angle of the drug. Because they put their reputation on the line.
Generic companies don’t care, they will combine the active ingredient with the cheapest binders because they are not required to do clinical trials.
When people experience side effects from the generics, generic companies deny any responsibility and blame on the brand manufacturer.
So I’m wondering if anyone in the pharmaceutical industry can confirm or deny these two very disturbing claims, namely:
A 40% fluctuation (80-120%) really allowed in the amount of active ingredient, and
The so-called “trade secret” binders that a brand manufacturer selects for its maximum effectiveness can legitimately be replaced with the shittiest, cheapest ones a generic company can find.
If either or both of these are true, than how can pharmaceutical reps honestly say with a straight face that there’s no difference? And if that’s true, then why is it so important to brand manufacturers to keep these secrets in the first place?
For the past four years he and I have had this very nice “You don’t fuck with me, I won’t fuck with you” thing going on. Unlike other doctors in my past who wanted to monitor my social drinking & scrutinize my familial relationships, he really believes that A.D.D. exists and that I have it.
So I try not too push it with complaints that I like one color pill better than another. I guess I also figured he’d just have the same blind faith in the pharmaceutical industries as the mindless clerks behind the counter, the difference being my doctor has the power to stop writing prescriptions if I get to be too much of a pain in the ass.
So last week I was floored when he initiated conversation on the very topic I’ve been biting my tongue about. He said a number of his other patients have complained about the round Adderall being inferior and he was wondering if I’d noticed any difference between it and the old kind. Of course, I then told him about all the negative side effects, how it turns me into a mindless drone, but it’s still slightly better than nothing because it at least prevents me from bouncing off the walls while I’m trying to analyze data and/or write about it.
After our appointment, I went upstairs to fill my prescription and I was doubly ecstatic to find out my pharmacy had switched back to the old orange/peach colored generics by Barr Laboratories.
Ever since my grad student insurance stopped covering off-campus pharmacies, I haven’t been able to afford to go to CVS or Wal-Mart for the Barr generics. So the other day after I filled my prescription was my first time with a non-crappy Adderall in over a year, and, I have to say, any doubts I’d had about the differences are completely gone. That pink shit really just makes me hate life. It also kind of changes who I am as a person, to some degree. For instance, I was always a casual horse racing fan, but for some reason over the last year (right about the time I had to switch permanently to CorePharma pink Adderall), I suddenly became totally obsessed with it. I mean, like, obsessed, as in, starting a new blog about it, making my own custom spreadsheets, trying to devise fancy new speed figures. It really is crazy how much time I’ve spent analyzing Past Performances, and how little time I’ve spent on the things that used to interest me before, such as politics, this blog, science and history, etc. Honestly, if the government wants a way to squash all dissent, they should totally just feed the shitty pink Adderall to the Michael Moores of the world. It really makes you not fucking care. At all.
And now, how strange that it only takes one week of being off of that stuff and suddenly it’s like awoken from a coma. I feel sharper, and able to think outside the box again. And I’m disgusted with how inert I’ve been since that awful CorePharma brand got inside me.
Anyway, I hope this isn’t just a temporary one-month thing with my pharmacy, and that the switch back to Barr (or to any other alternative to the pink CorePharma Adderall) will be permanent.
My doctor asked why I didn’t mention anything to him sooner, and I guess I really definitely should have. And you should too, if you’re among the hundreds of people who’ve commented on my other posts (linked to throughout this entry) that these differences are real and not just in our heads.
Even if you’re afraid to talk to your doctor about it, as I was, just keep talking about it to someone, anyone who will listen. And don’t let the bastards get you down, or convince you it’s your fault.
As for horse racing, I feel like I’m totally not into it. Seriously. There were several major, Grade I, Breeders’ Cup Win & You’re In races in Canada on Saturday, and I haven’teven bothered to check the website to find out who won. Yet somehow, there are still those who say the differences between these two generics are miniscule, or imagined. I’m sorry but, with due respect to those simpletons, this is no placebo! If my passions and hobbies completely change depending on which generic medicine is cheaper for my pharmacy that month, the two medications are not interchangable!
Barr Laboratories, Inc. issues a voluntary nationwide recall of Dextroamphetamine/ Amphetamine 20mg Tablets, Lot number 311756
August 13, 2009 – Barr Laboratories, Inc. is initiating a voluntary recall of Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate (Mixed Salts of a Single Entity Amphetamine Product) 20mg Tablets, 100 count bottles, lot number 311756. The product identified is being recalled because the affected lot may contain some tablets exceeding weight requirements which may lead to super-potent tablets.
….
According to this article in Philadelphia Business Journal:
“(O)n Thursday, Teva Pharmaceutical Industries became the first company to launch a generic version of Shire’s attention deficit-hyperactivity disorder drug Adderall XR.”
For one, the pink generic Adderall was noticeably different from its orange predecessor. Moreover, I simply do not believe the standard industry line that generic medications are “exactly the same” as their branded counterparts, given the leeway that generic drug producers have when it comes to binders and fillers.
The thousands of responses I received to my posts on this topic indicate that others tend to agree. I’m wondering if some of these same issues arose (or are arising) with the generic extended release form of Adderall.
The new generic Adderall XR is produced by Teva Pharmaceutical Industries, a pharmaceutical company based in Jerusalem that mergered with Barr Pharmaceuticals in 2008. Barr laboratories had previously produced a generic Adderall immediate release, which I found less unpleasant than CorePharma’s pink Adderall.
But it’s also noteworthy that Teva was sued by Shire Laboratories in 2006 over patent issues. Shire was the original patent holder for brand named Adderall. It was around that time that many of us first began to notice the difference between generic and brand Adderall. (I sure hope the clowns at CorePharma weren’t tinkering with the recipe to avoid lawsuits.)
I can’t speak from personal experience regarding Teva’s new generic Adderall XR, but early reports from friends and associates of mine are that “The timed release went generic and now it sucks.”
The Food & Drug Administration has a contact page. People who notice these sorts of problems are encouraged to notify the FDA.
Life doesn’t feel linear to me. There’s always something big I was working toward “yesterday.” But my goals don’t stay the same long enough to see anything through. I get too good at things and they suddenly bore me; or, I suck at them for too long and the daunting task of improving overwhelms me, so instead of working at it I swear off the whole activity as pointless and lame. Whatever the outcome, the person I am “today” never cares. He just scoffs at yesterday’s efforts as futile.
I have a Word document that’s 268 pages long. It contains all my half-written blog entries from my change-the-world phase. I’d get a thought in my head that I’d think was brilliant, and then I’d start typing it all out. But as I was writing I’d gradually start to lose my interest in it.
Now I’m sort of afraid to go back and read all these unfinished thoughts. Inside those pages lies an answer I don’t want to know. It’s been long enough now that reading them will be almost like reading something new for the first time. If I’m not as wowed by my words as I was while I wrote them, it will tell me something useful—that all that time I thought I was saying something, I was really saying nothing at all. It’s just noise now; just nonsensical words, from a self-important, self-absorbed person who lacked the ability to assess himself accurately.
I’m entering a new phase in my life. Things are different again. As usual I don’t know what I want, or maybe this time I just want nothing. That’s not it; I want something…
I want to believe the “happiness” I choose to pursue in life, can actually make me happy. Otherwise, what is the point, really? Wake up just to avoid sleeping all day? No.
I want to believe in what I’m doing again—even if what I’m doing is truly pointless as hell. I can still hear the keyboard tapping away, blank chatter in the dark night silence, when I could have been living or loving, or at least working.
Gradually, my my lack of confidence in the pharmaceutical industry has extended from the less-than-forthright “experts”, to the franchises like Walgreen’s, and now, to the foot-soldiers behind the counters. Most of them are just good folks trying to make an honest buck; when I myself was a corporate foot-soldier at Six Flags Amusement Parks, my goal was to get through the day using as little effort as possible. I wanted it to be mindless and I hated it when fatasses bitched because their ice cream cones had too few or too many sprinkles. So in a way I can understand the frustration, when you’re expecting to have a mindless day and get paid for it, and then some unconventional jerk has to come along with a customized dilemma that makes it unpredictable. Unfortunately though there’s a difference between fussy Food Court nitpickers, and medical patients with legit concerns about their medications. Maybe, when it comes to sprinkles and ketchup packets, the customers should occasionally take one for the team. But with regard to the legal production and sales of Class II narcotics, it feels more like the team is taking one for “The Man” & corporate America. Somehow the industry even turned our foot-soldiers against us, as the behind-the-counter pharmacists-in-training have grown impatient towards the clientele, much like my disdain for the sprinkle-demanders.
A recent comment by the boldly-named “Anonymous” demonstrates their dismissive mentality.
“You’re all fucking idiots, if I you came to the pharmacy counter bitching about this I’d tell you to get lost before I call the cops.”
Good idea. I’m sure they’d love to hear from you, especially if your town is as dull as your ignorance suggests.
Dispatcher: “East Backwater P.D. What is your location?” Anonymous Minion: “Uh… wuh… I’m at the Walgreen’s on Hillbilly Road.” Dispatcher: “Okay. And what’s your emergency?” Anonymous Minion: “Um, I have a grad student here, and…” Dispatcher: “… are you being robbed?!” Anonymous Minion: “No, but…” Dispatcher: “Do you feel threatened?” Anon. Minion: “No, well, sort of… he’s… asking me questions.” Dispatcher: (pause) “Pardon?” Dispatcher: (pause) “As in, sexually inappropriate/creepy stalker questions?” Anon. Minion: “Well no, just… questions about his medication that I find annoying. Can you arrest him?” Dispatcher: “You’ll have to be more specific. What is the emergency?” Anon. Minion: “He’s claiming based on his experiences with two different brands that one’s different than the other. I personally disagree. This customer’s questions are too hard, and I get very scared when people aren’t satisfied with the generic responses I’ve been ordered to memorize. eel insecure Can you please send someone immediately?” Dispatcher:“Alright… well, right now our lone ranger Officer Billy Bob’s gone to rescue a cat from a tree. But if you stay on the line I’ll try to talk you through this.” Anon. Minion:“Okay, good. Thankyouthankyouthankyou.” Dispatcher:“Now, do you see that name tag on your Walgreen’s uniform?” Anon. Minion:“The one that says ‘Happy to Answer Your Questions.’” Dispatcher: “Yes, that one. I need you to take it off.” Anon. Minion:“Okay, it’s off. Now what?” Dispatcher: “Now, look around for the dumbest-looking person in the store that you can find.” Anon. Minion: “I see a toddler. I bet he’s pretty dumb, prolly.” Dispatcher:“Excellent, give your pharmacy badge to the two-year-old!” Anon. Minion: “Why?” Dispatcher:“Because he’s more qualified to wear it than you are!”
Usually people who leave thoughtless, nonconstructive comments are just “trolls” who pop in to stir things up and never bother to come back and follow-up on their shit-talk. But I really hope this troll comes back and reads this, even if he or she concludes (as I myself have) that I am lame for devoting several paragraphs to a single sentence of prattle.
It’s true; this post was basically pointless. A colossal waste of time. Instead of being productive this morning, I’ve scripted a dialog between a stranger I’ll never meet and a dispatcher who doesn’t exist.
But in a bizarre way it does prove my point.
I have A.D.D., remember, and tend to get sidetracked easily. And while they have medicines for that, unfortunately the pink Adderall sold to me by corporations like the one this simpleton probably works for, does not work. The CorePharma higher-ups know it already. Some of the psychiatrists who prescribe these drugs must undoubtedly have their suspicions. Consumer “feedback” is a bitch, but a quite powerful one. And when the shit hits the fan for this industry,as it no-doubt soon will, even the anonymous shit-for-brain clerks at the bottom of the pharmaceutical totum pole will have to start doing their jobs again.
I’ve long wondered if AD/HD is a myth or exaggeration.Sure, they tell us that Adderall is useful only to people with attention-deficit disorder, but clearly this is false.On college campuses, use of stimulants is rampant.To tell the truth, I’ve never met someone who did not benefit cognitively from Adderall. Which begs the question: what’s so special about me that I deserve this cognative advantage over non-A.D.D.-people who cannot legally take Adderall?
Last Tuesday on NPR’s On Point, host Tom Ashbrook tackled the issue of “mind-enhancers,” and the likelihood that they’ll soon be available to everyone—not just those of us with AD/HD.The show’s guests included:
Gibson focused on the business aspect.It’s not just the pharmaceutical companies that want to see this change occur; business managers now see the benefits as well.There is big money in drugs, and the pharmaceutical industry is constantly focusing on the next big thing.We have drugs that help aging housewives remove wrinkles or aging baseball players break homerun records; pills that can renew anything from a thinning hairline to a floppy penis.Gibson points out, practically, that it’s only a matter of time before drugs that enhance the human mind are as widespread and accepted as those that enhance the body. The present generation of college students is already on-board with the notion of using drugs to study, whether they have A.D.D. or not.There’s little reason to believe they’ll change their habits upon entering the work force.Already, stimulants are revolutionizing some of the most sought after and respected career fields. From doctors to lawyers to scientists—even fighter jet pilots—all are known to rely on A.D.D. drugs to maximize their effectiveness and productivity.
Next, Martha Farah described the shift that’s required in our collective thinking, if widespread use of stimulants is to take off in the coming decade.For Farah, the issue is in part a philosophical one.She and her colleagues reject the idea that “enhancement” must be treated as taboo.They liken pharmaceutical mind-enhancers to other means of self-improvement: including education, exercise, sleep, and nutrition. Ultimately, Farah agrees with Gibson that the transformation is “inevitable”—human beings are warming up to drugs that improve mental functioning.
Against Farah and Gibson, Thomas Murray presented a rather bleak future scenario in which everyone has to take drugs in order to be competitive and employable.That’s exactly what happens the sports world, Murray explains, as athletes take steroids more out of necessity than free will.When all of one’s opponents are advantaged in some specific way, it’s awfully hard to deny oneself of that same enhancement.
Adderall and Ritalin clearly offer a competitive advantage.Certainly Adderall can’t make you smarter than everyone, but it definitely turns you into a sharper version of yourself.If I can only do the things I do on Adderall, what happens if everyone else can take it, too?
Finally, Murray poses a question about our education system and the nature of learning.Should education be about memorizing and regurgitating information?By focusing solely on this aspect of learning, are we stifling other forms of intellectual growth, creativity, critical thinking, the ability to connect with ourselves and others?
This very dilemma has troubled me for some time now, as I’ve felt the reigns of academia choking me and smothering me.I used to feel connected to the world and yet still uniquely me.Now, somedays, I feel that I am neither–more like a robot with a brain on autopilot.
All in all, the NPR program touched on a number of pertinet questions, and I enjoyed hearing the back and forth from both sides. You can listen to the segment here.
I’ve gone north to New England for the holidays. Right now I’m at my old desk, in a high school bedroom that remains forever stuck in 1999. I’m looking out the window at the new white snow, and at the old crows tiptoeing around on it.
At first there was just one bird. Now I see four, five, six of them. They’re lined up on the strip of yard my dogs use as a bathroom, taking turns picking up and carrying away pieces of whatever my golden retrievers deposited this morning. For some reason, this captivates me. It’s like an outdoor grocery store, but the lines are shorter and the food is shittier, and the customers seem less bitchy.
And in at least one way, I wish I could be those crows. Morning finds them content and without expectations, comprehending little about their world. I know far too much about mine, and from it I expect more than I deserve, more than it can give or cares to offer.
Insulated, I sit here in my warm capsule and stare at aging walls. The things hanging on them reflect who I used to be a decade ago, as does too much of what I write. I reflect on how I’ve changed, but can I ever change enough?
And I worry about things trivial to birds and bees. I worry about the coming holiday, I won’t come bearing gifts. I worry about milestones, diamonds I couldn’t afford and didn’t want to, and what that may mean. I hope my company and companionship can substitute for diamonds, hope my heart alone can be enough for one more year, a surrogate symbol, proxy validation for sisters and aunts who prefer to look at rings, eyes that only understand promises when they shimmer.
I worry about my dissertation and whether or not some academic journal no one reads will decide to honor my submission with a “Revise and Resubmit.” As if that way lies wisdom…
But wiser creatures, they don’t live like this. I envy the crows, naked and homeless as they are. For them, stumbling upon a dog turd during their daily trek barefoot through the snow brings genuine happiness (or, at least, more than I might expect to find if and when I see my name in print in the Journal of Contemporary Ethnography).
And if ever there might be some perspective in this crazy world I try to live in, it will be neither my past nor future nor parents nor friends nor lovers, who come along to provide it for me. My role models today are the impromptu custodians in my backyard, naked and homeless indeed, and for the moment they keep my head strangely clear. But serenity soon will fly off with the birds that brought it to me. They are like me in the end. They too eventually will hunger for more.
This is the first of a two-part blog entry on “Therapeutic Interchange.” Part 1 gives an overview of the common medical practice of therapeutic interchange. Part 2, to be written sometime within the next week, will discuss how this practice relates to our discussions about the differences between generic pink Adderall (by CorePharma) and generic orange Adderall (by Barr Laboratories).
Tonight I came across this CBS News video about a shady—but apparently common—medical practice known as therapeutic interchange.Therapeutic interchange means swapping out one prescription drug for another when the two meds are reasonably similar.CBS News correspondent Sharyl Attkisson explains that hospitals do this in order to make money for themselves and the drug companies.
According to , the practice of therapeutic interchange places profit over a patient’s wellbeing, and ultimately costs taxpayers hundreds of millions of dollars. He calls therapeutic interchange “business-as-usual for the hospitals and drug companies in the United States of America today.” Dr. William LaCorte recently won a lengthy court case against a major pharmaceutical company, after “therapeutic interchange” sent one of LaCorte’s patients into a coma.
The doctor’s saga began over a decade ago in Louisiana, when he caught New Orleans’ Memorial Hospital modifying the prescriptions he’d written.Specifically, whenever LaCorte prescribed Zantac to his patients, Memorial switched it to Pepcid.
Pepcid and Zantac are similar in that both drugs are acid blockers, and both can prevent dangerous internal bleeding. At the doses recommended for Zantac, however, Pepcid is too strong for some people.One of Dr. LaCorte’s patients wound up in a coma, presumably as a result of the ill-advised therapeutic interchange.
When LaCorte inquired as to why his patients were consistently being given a different drug tfrom the one he’d prescribed for them, the doctor learned that Pepcid’s manufacturer (Merck) had entered into a “market share” deal with the Memorial Hospital.The drug company offered the hospital a significant discount on its products; in exchange, Memorial promised that 80 percent of the hospital’s antacid patients would be put on Pepcid.
Dr. LaCorte said the hospital tried to put nearly every patient who needed prescription medication on the Merck brand of whatever type of drug they needed.
LaCorte complained to anyone and everyone he could think of, to no avail.No one in the industry cared enough to do anything about it, or to follow-up.(We who have been having Adderall drama—with the pink generic brand, CorePharma—know what that’s all about).But finally, LaCorte called the feds, because as it turned out, this “market share” deal didn’t just hurt patients who suffered from taking the wrong medications. Finally, he got the feds involved, and charged Merck with defrauding taxpayers.Pepcid was twice as pricey as Zantac.Since many patients were on Medicare or Medicaid, taxpayers had to cover the difference.
William LaCorte waged a lengthy legal fight against Merck and this now prevalent medical practice.Only recently, after a twelve-year court battle, did Merck finally agree to reimburse taxpayers $650 million dollars for deals to get hospitals nationwide to favor their products over those of their competitors.Apparently, Merck was doing this not only with Pepcid, but also with Zocor and Vioxx. (You may recall that Vioxx had many harmful side effects and was eventually taken off the market.)Per U.S. law for whistleblowers, LaCorte can receive as much as 25-30% percent of whatever the government recovers.
I tossed and turned all night last night, despite 3 Tylenol PMs and two swigs of NightTime Cough Syrup. Not exactly the perfect recipe for jolly-mooded mornings. I can’t remember the last time I woke up happy, excited about the day.
There’s a phase we all go through in life where it’s okay to be indecisive and still asking questions and even on the wrong track. That phase is ending for me now and I’m entering into the one that follows, where doubt swells into anxiety but then relaxes into a comfortable depression, where fears are accepted as simply the way things are. Reality.
So in the night when I toss and turn because the world isn’t as I think it should be, maybe I can find peace in fitting in, being more like most people I meet, who never realized their dreams, or never had any.